Initial: 25 mg/2 mg or 25 mg/4 mg PO TID/QID, OR 50 mg/4 mg PO BID. Maintenance: 2 mg/25 mg or 4 mg/25 mg PO BID/QID, OR 50 mg/4 mg PO BID. Initial: 50 mg/8 mg (ie, 2 tablets of 25 mg/4 mg) PO BID/TID; if needed a fourth dose may be given at bedtime.
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Discuss the pharmacology of methotrexate. Describe the current incidence and presentation of high-dose methotrexate-induced renal dysfunction. Discuss conventional and investigational treatment approaches to high-dose methotrexate-induced renal dysfunction. Access and take the CME test online and receive 1 AMA. Case 1.
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